Neuronal Mechanisms of Nociceptive-Evoked Gamma-Band Oscillations

Li Hu, PhD, is a Professor at the Institute of Psychology, Chinese Academy of Sciences (CAS). He received his PhD from the University of Hong Kong in 2010 and has been a principal investigator at the Institute of Psychology (CAS) since 2016. His research focuses on unraveling the cognitive and neural mechanisms underlying pain perception and its modulation. Employing advanced cross-species paradigms, multimodal neuroimaging techniques, and cognitive neuromodulation approaches, his work mainly aims to identify reliable neural indicators associated with pain sensitivity and discriminability. Additionally, he actively investigates novel non-pharmacological analgesic strategies, such as neuromodulation and cognitive-behavioral interventions, and explores the underlying neural mechanisms that drive their efficacy. His research was been supported by the National Key Research and Development Program of China, the National Natural Science Foundation of China, the Beijing Natural Science Foundation, and industry collaborations.

David A. Seminowicz, PhD, is Professor and Wolfe-Western Fellow, Department of Medical Biophysics, Schulich School of Medicine & Dentistry, University of Western Ontario. He earned a BSc from the University of Guelph, a PhD at the University of Toronto and completed postdoctoral training at McGill University. He was faculty at University of Maryland, Baltimore, from 2010-2022. He was also Principal Research Scientist at Neuroscience Research Australia, in Sydney, from 2019-2022. His work has focused on the cognitive aspects of pain, individual differences in the response to pain, and the consequence of chronic pain on brain structure and function. His studies have clarified how pain-related and cognitive-related brain activity interact and how passive and active pain coping strategies affect these types of activity. His work further suggested a brain mechanism through which chronic pain might affect cognitive ability and continues testing this hypothesis in intervention studies in people with chronic pain. The clinical populations in these studies include chronic low back pain, chronic and episodic migraine, and burning mouth syndrome. Dr. Seminowicz has also used rodent MRI to ask a question that could not easily be addressed in humans, such as how the brain changes over time from before the onset of an injury that leads to chronic pain to the time when the disease affects cognitive and affective behaviors. Ongoing studies in Dr. Seminowicz’s lab employ longitudinal designs to assess how interventions affect brain function and whether pain biomarkers can be developed. Another line of work examines the role of the claustrum in cognitive control and pain. The main techniques in his lab include quantitative sensory testing, EEG, structural and functional MRI, and simultaneous EEG-fMRI. His main funding has been from the NIH, CIHR, NSERC, intercampus initiatives, private foundations, and industry.