Epigenetics and ‘Omics: The Personalized Molecular Pathways of Pain Regulation

This master class explores the molecular role of epigenetics and proteins in the development, maintenance, and increased susceptibility to chronic pain. 

Dr. Giordano will focus on the involvement of epigenetic changes in patients with musculoskeletal pain and the possibility to evaluate these changes in human pain models. During this session, Dr. Giordano will share research and evidence on how epigenetic mechanisms can influence pain pathways and responses and discuss the opportunity to discover targeted epigenetic interventions and their potential in managing and treating pain disorders.

Prof. Géranton 's session will guide us through trauma-induced epigenetic changes, focusing on the intricate molecular changes occurring following stress exposure, during the critical early years of life but also in adulthood. Attendees will gain insights into how these epigenetic modifications may influence susceptibility to pain chronicity. This knowledge opens new doors in understanding the long-term implications of stress exposure, particularly in early-life, on the susceptibility to chronic pain.

Prof. Ghafouri, as our final speaker, will provide an in-depth overview of the latest advancements in proteomics in the context of chronic pain research. Prof. Ghafouri's lecture will focus on the exciting potential of proteomic techniques to identify novel pain-related biomarkers, unravel intricate pain pathways, and uncover therapeutic targets for more effective pain management strategy.

Faculty:

• Lars Arendt-Nielsen
• Rocco Giordano
• Sandrine M. Geranton
• Bijar Ghafouri