Pain, Sex and Death

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Includes a Live Web Event on 11/05/2025 at 5:00 PM (EST)

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5 November 2025 at 5:00 p.m. EDT

Free to IASP members; Non-members $25 USD

Pain researchers have now come to some consensus regarding the existence of sex/gender differences in the sensitivity to and tolerance of pain in humans. In addition and more importantly, evidence is rapidly emerging that the sexes may differ qualitatively in their biological mediation of pain and analgesia. That is, different genetic factors, neural circuits, neuromodulators, and immune cells may be relevant to pain processing in males and females. I will make the case for the importance of sex-as-a-biological-variable policies as they pertain to pain, and then present several research stories suggestive of fundamental sex dimorphism in pain processing, the effects of pain on mortality, and the interaction between pain and social behaviour.

Speaker:

Jeffrey S. Mogill, PhD, FCAHS, FRSC, Professor, McGill University

Jeffrey S. Mogill, PhD, FCAHS, FRSC

Professor

McGill University, Montreal, Canada

Jeffrey S. Mogil is the E.P. Taylor Professor of Pain Studies and a Distinguished James McGill Professor at McGill University, where he formerly directed the Alan Edwards Centre for Research on Pain. He earned a B.Sc. (Honours) in Psychology from the University of Toronto (1988) and a Ph.D. in Neuroscience from UCLA (1993), completed a postdoctoral fellowship in Portland, Oregon (1993–1996), joined the University of Illinois at Urbana–Champaign faculty, and moved to McGill in 2001. A Fellow of the Royal Society of Canada and the Canadian Academy of Health Sciences, Dr. Mogil is renowned for seminal work in pain genetics, sex differences in pain and analgesia, and algesiometric testing in mice; he authored landmark reviews and edited the first textbook in the field, The Genetics of Pain (IASP Press, 2004). He has published 270+ papers and chapters since 1992, delivered nearly 400 invited lectures, holds an h-index of 100 (Google Scholar), and his work has been cited 40,000+ times; a 2022 Stanford analysis ranked him 7th in Anesthesiology and 210th in Neuroscience worldwide. His research has been supported by NIH, CIHR, NSERC, and leading foundations; current support includes a CIHR Foundation Grant, NSERC Discovery Grant, CIHR Sex and Gender Science Chair, and LAEF. Honors include major awards from IASP, CPS, and APS. He has served as Section Editor (Neurobiology) for Pain, chaired the 13th World Congress on Pain Scientific Planning Committee, sat on the IASP Council, and founded the North American Pain School.

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Webinar 1
11/05/2025 at 5:00 PM (EST)  |  90 minutes
11/05/2025 at 5:00 PM (EST)  |  90 minutes Pain researchers have now come to some consensus regarding the existence of sex/gender differences in the sensitivity to and tolerance of pain in humans. In addition and more importantly, evidence is rapidly emerging that the sexes may differ qualitatively in their biological mediation of pain and analgesia. That is, different genetic factors, neural circuits, neuromodulators, and immune cells may be relevant to pain processing in males and females. I will make the case for the importance of sex-as-a-biological-variable policies as they pertain to pain, and then present several research stories suggestive of fundamental sex dimorphism in pain processing, the effects of pain on mortality, and the interaction between pain and social behaviour.
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